From North West (Pisa- Livorno) : reach Pisa- Livorno on the Tirrenica coast and go on for Grosseto on the S.S.1 Aurelia. From Grosseto take S.S. 223 towards Siena.

From North East (Florence or Adriatico): reach Florence and take highway Firenze Siena. Once in Siena, take S.S. 223 towards Grosseto.

Southcoming: reach Rome and go on the highway till Civitavecchia, where you will take S.S. 1 Aurelia towards Grosseto. From Grosseto take S.S 223 for Siena.